Graphene, boron nitride, dichalcogenides and other inorganic 2D layered materials (2DLM) have atomically thin structure with unique electrical, mechanical, thermal, and optical properties, and have already been extensively explored for electronics, sensing, catalysis and biomedical applications. On the other hand, in the polymer world, there is an emerging class of 2D polymers with analog structure to 2D layered materials.
This project entails developing plant based vaccines using smart genomics. Vaccines are essential for protecting all segments of the civilian population from pandemic influenza to other emerging infectious diseases.
The Joy Lab has developed a platform of polyesters and polyurethanes that are being utilized for the incorporation and sustained delivery of therapeutics. The undergraduate student working on the project will work specifically towards the synthesis of the polymers, incorporation of the therapeutic within the polymer and analyze the release kinetics. The student will gain experience in synthesis and characterization of polymers and in the analysis and interpretation of experimental data.
Our team has developed flexible, lightweight fabric materials that can selectively determine physiological information from sweat forming on the surface of the skin. The technology is the first lightweight fabric sensor to provide real-time information regarding hydration levels during exercise or training through selective determination of sodium ion levels.
Employing an in vitro swelling assay, cell volume will be assessed after manipulating CHDH and BGT-1 activity in hypertonic conditions to examine the direction of the fluid transport through the cell membrane by live imaging using confocal microscopy followed by analytical quantification of betaine.
What is the osmolality of CSF, extracellular fluid (ECF), fluid from syrinx in syringomyelia/PTSM rats? The fluids mentioned above will be harvested from the rats having syringomyelia, the osmolality of those fluids will be determined using osmometer. The study of osmolality of fluids will explain the potential syrinx formation/expansion mechanism.
We use a bioengineering approach to develop biomimetic three-dimensional tumor models to understand the disease biology and test and identify novel treatments. We are an interdisciplinary team of graduate and undergraduate students tackling a very significant problem using a combination of biomedical and biological approaches.
Nanoparticles (NPs) are used widely in cosmetics and for drug delivery and thus come in contact with blood and other fluids in the body. NPs present in biological fluids rapidly interact with proteins, which undergo structural changes upon binding to the NPs. These conformational (structural) changes of the protein determine the biological responses of the NPs in the living system.
This project involves current work with Akron Children’s Hospital (ACH), and entails finding new and cost-effective ways of diagnosing pediatric sleep apnea using new tools such as low-cost Arduino micro-processors, new low-cost sensors, wireless technology, advanced signal procssing algorithms such Wavelets, etc. Selected students will work within a research group and may be onboarded at ACH so that they can help in clinical tests at the hospital.
Mechanical stress is ubiquitously present in materials and biological systems, and the force-induced bond scission and materials failure have been extensively studied. In recent years, utilizing mechanical force to do targeted and constructive chemistry, largely fueled by the concept of mechanophore, i.e., stress-responsive moiety, has become a new trend.
In this project the student will conduct experiments to determine how lipid content is coupled to membrane protein function. Cultured cells will be supplemented with different lipid inputs, and the effects on membrane proteins will be measured using quantitative biophysical methods. This project is part of a collaborative research grant focused on neurological pathologies associated with brain lipid composition.
Our lab focuses on tissue engineering methods to improve nerve regeneration. Undergraduates working on these projects have focused on material or cellular aspects, depending on interest and skill. We work both in vivo and in vitro, on optic and peripheral nerve, and both neural and embryonic stem cells.