Next generation nanocomposites based on 2D polymers and 2D inorganic materials

Graphene, boron nitride, dichalcogenides and other inorganic 2D layered materials (2DLM) have atomically thin structure with unique electrical, mechanical, thermal, and optical properties, and have already been extensively explored for electronics, sensing, catalysis and biomedical applications. On the other hand, in the polymer world, there is an emerging class of 2D polymers with analog structure to 2D layered materials.

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Design of polyester scaffolds for encapsulation and release of therapeutics

The Joy Lab has developed a platform of polyesters and polyurethanes that are being utilized for the incorporation and sustained delivery of therapeutics. The undergraduate student working on the project will work specifically towards the synthesis of the polymers, incorporation of the therapeutic within the polymer and analyze the release kinetics. The student will gain experience in synthesis and characterization of polymers and in the analysis and interpretation of experimental data.

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Wearable Health Sensors

Our team has developed flexible, lightweight fabric materials that can selectively determine physiological information from sweat forming on the surface of the skin. The technology is the first lightweight fabric sensor to provide real-time information regarding hydration levels during exercise or training through selective determination of sodium ion levels.

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To investigate the osmoregulatory conditions of fluids associated with syringomyelia pathology in the PTSM rat model (In vivo study)

What is the osmolality of CSF, extracellular fluid (ECF), fluid from syrinx in syringomyelia/PTSM rats? The fluids mentioned above will be harvested from the rats having syringomyelia, the osmolality of those fluids will be determined using osmometer. The study of osmolality of fluids will explain the potential syrinx formation/expansion mechanism.

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Nanoparticles In the Human Body: Blood Plasma Proteins Binding on Titanium Dioxide

Nanoparticles (NPs) are used widely in cosmetics and for drug delivery and thus come in contact with blood and other fluids in the body. NPs present in biological fluids rapidly interact with proteins, which undergo structural changes upon binding to the NPs. These conformational (structural) changes of the protein determine the biological responses of the NPs in the living system.

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Improved techniques for early and cost effective diagnosis of pediatric sleep apnea

This project involves current work with Akron Children’s Hospital (ACH), and entails finding new and cost-effective ways of diagnosing pediatric sleep apnea using new tools such as low-cost Arduino micro-processors, new low-cost sensors, wireless technology, advanced signal procssing algorithms such Wavelets, etc. Selected students will work within a research group and may be onboarded at ACH so that they can help in clinical tests at the hospital.

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Mechanochemistry of a helical metal-ligand complex

Mechanical stress is ubiquitously present in materials and biological systems, and the force-induced bond scission and materials failure have been extensively studied. In recent years, utilizing mechanical force to do targeted and constructive chemistry, largely fueled by the concept of mechanophore, i.e., stress-responsive moiety, has become a new trend.

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Lipid modulation of membrane protein properties

In this project the student will conduct experiments to determine how lipid content is coupled to membrane protein function. Cultured cells will be supplemented with different lipid inputs, and the effects on membrane proteins will be measured using quantitative biophysical methods. This project is part of a collaborative research grant focused on neurological pathologies associated with brain lipid composition.

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